Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5311
Gene Symbol: PKD2
PKD2 		0.970 Biomarker disease BEFREE We generated the first inducible, smooth muscle-specific knockout mice for a TRP channel, namely for PKD2 (TRPP1), to investigate arterial myocyte and blood pressure regulation by this protein. 30511640 2018
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.010 GeneticVariation disease BEFREE We demonstrated that this novel HNF-1β mutation strongly influences the expression of both PKD2, responsible for the formation of the renal cysts, and SOCS3, which is associated with early diabetes onset. 22641569 2013
Entrez Id: 5311
Gene Symbol: PKD2
PKD2 		0.970 Biomarker disease GENOMICS_ENGLAND Type of PKD1 mutation influences renal outcome in ADPKD. 23431072 2013
Entrez Id: 5311
Gene Symbol: PKD2
PKD2 		0.970 Biomarker disease MGD Two populations of node monocilia initiate left-right asymmetry in the mouse. 12859898 2003
Entrez Id: 5310
Gene Symbol: PKD1
PKD1 		0.370 Biomarker disease BEFREE Two major genes have been identified and characterized in detail: PKD1 and PKD2, mapping on chromosomes 16p13.3 and 4q21-23, respectively. 11438989 2001
Entrez Id: 5310
Gene Symbol: PKD1
PKD1 		0.370 Biomarker disease CTD_human Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways. 19401297 2009
Entrez Id: 5311
Gene Symbol: PKD2
PKD2 		0.970 GeneticVariation disease BEFREE These findings suggest that the first step toward cyst formation in PKD2 patients is the loss of one functional copy of polycystin-2. 9326320 1997
Entrez Id: 5311
Gene Symbol: PKD2
PKD2 		0.970 GeneticVariation disease UNIPROT These findings suggest that the first step toward cyst formation in PKD2 patients is the loss of one functional copy of polycystin-2. 9326320 1997
Entrez Id: 5311
Gene Symbol: PKD2
PKD2 		0.970 Biomarker disease CTD_human Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD. 25877301 2015
Entrez Id: 5310
Gene Symbol: PKD1
PKD1 		0.370 Biomarker disease CTD_human Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD. 25877301 2015
Entrez Id: 23476
Gene Symbol: BRD4
BRD4 		0.300 Biomarker disease CTD_human Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD. 25877301 2015
Entrez Id: 4609
Gene Symbol: MYC
MYC 		0.300 Biomarker disease CTD_human Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD. 25877301 2015
Entrez Id: 5311
Gene Symbol: PKD2
PKD2 		0.970 Biomarker disease CTD_human The TRPP2-dependent channel of renal primary cilia also requires TRPM3. 30883612 2019
Entrez Id: 5311
Gene Symbol: PKD2
PKD2 		0.970 GeneticVariation disease UNIPROT The polycystin complex mediates Wnt/Ca(2+) signalling. 27214281 2016
Entrez Id: 5310
Gene Symbol: PKD1
PKD1 		0.370 Biomarker disease CTD_human The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. The European Polycystic Kidney Disease Consortium. 8004675 1994
Entrez Id: 5311
Gene Symbol: PKD2
PKD2 		0.970 Biomarker disease MGD The ion channel polycystin-2 is required for left-right axis determination in mice. 12062060 2002
Entrez Id: 9033
Gene Symbol: PKD2L1
PKD2L1 		0.020 GeneticVariation disease BEFREE The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism. 10602992 2000
Entrez Id: 5310
Gene Symbol: PKD1
PKD1 		0.370 GeneticVariation disease BEFREE The PKD1 children had, in comparison with those with PKD2, significantly greater total of renal cysts (13.3 +/- 12.5 vs 3.0 +/- 2.1, P = 0.004), larger kidneys [right/left kidney length 0.89 +/- 1.22 standard deviation score (SDS) vs 0.17 +/- 1.03 SDS, P = 0.045, and 1.19 +/- 1.42 SDS vs 0.12 +/- 1.09 SDS, P = 0.014, successively] and higher ambulatory day-time and night-time systolic BP (day-time/night-time BP index 0.93 +/- 0.10 vs 0.86 +/- 0.05, P = 0.021 and 0.94 +/- 0.07 vs 0.89 +/- 0.04, P = 0.037, successively). 19194729 2009
Entrez Id: 5311
Gene Symbol: PKD2
PKD2 		0.970 Biomarker disease MGD Somatic inactivation of Pkd2 results in polycystic kidney disease. 9568711 1998
Entrez Id: 220963
Gene Symbol: SLC16A9
SLC16A9 		0.010 Biomarker disease BEFREE SLC17A1, SLC17A3, SLC17A4, SLC22A11, and SLC2A9 were involved in both pathways, and PKD2 and SLC16A9 in one pathway. 22609445 2012
Entrez Id: 56606
Gene Symbol: SLC2A9
SLC2A9 		0.010 Biomarker disease BEFREE SLC17A1, SLC17A3, SLC17A4, SLC22A11, and SLC2A9 were involved in both pathways, and PKD2 and SLC16A9 in one pathway. 22609445 2012
Entrez Id: 5311
Gene Symbol: PKD2
PKD2 		0.970 GeneticVariation disease UNIPROT Seven novel mutations of the PKD2 gene in families with autosomal dominant polycystic kidney disease. 10411676 1999
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.300 Biomarker disease CTD_human Rosiglitazone inhibits cell proliferation by inducing G1 cell cycle arrest and apoptosis in ADPKD cyst-lining epithelia cells. 20210794 2010
Entrez Id: 5311
Gene Symbol: PKD2
PKD2 		0.970 GeneticVariation disease BEFREE Refining the localization of the PKD2 locus on chromosome 4q by linkage analysis in Spanish families with autosomal dominant polycystic kidney disease type 2. 7825585 1995
Entrez Id: 5311
Gene Symbol: PKD2
PKD2 		0.970 GeneticVariation disease UNIPROT Polycystin-2 is an intracellular calcium release channel. 11854751 2002